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Nucleic Acid Testing Markets in Hong Kong

DateJun, 2006
Pages0
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Abstract:
 This Frost & Sullivan research service entitled Nucleic Acid Testing Markets in Hong Kong gives an overview of the current status of the nucleic acid testing market in Hong Kong and discusses present and potential revenues. The study also discusses the prevailing industry challenges and gives an overview of the reimbursement system and regulatory environment for NAT in Hong Kong.

Market Sectors

Expert Frost & Sullivan analysts thoroughly examine the following market sectors in this research:

By Application:

- Polymerase Chain Reaction (PCR)

- RT-PCR

- Other Platforms

Technologies

The following technologies are covered in this research:

- Nucleic Acids: Various high molecular weight acids, such as DNA and RNA, found in all living cells as well as viruses and made up of nucleotide chains, which carry genetic information.
- Nucleic Acid Testing (NAT): Nucleic acid-based amplification test.
- Polymerase Chain Reaction (PCR): A revolutionary technology, which generates multiple copies of a specific nucleotide sequence from a target organism and able to detect trace elements of target organisms with high specificity. Applications include biological research, clinical diagnostics, forensics, and genetics.
- RT-PCR: Real-time measurement for PCR, through quantitative detection of specific nucleic acid sequences and permits accurate and informative measurements for DNA or RNA quantification. Real-time applications include measuring gene expression and detecting bacterial or viral load within samples.
- bDNA: Amplified detection of minute quantities of genetic material (DNA or RNA) and direct quantification of virus in serum or plasma. Distinct from PCR due to the measurement of the virus present through amplification of signals, rather than target sequences.
- Enzyme-linked Immunosorbent Assay (ELISA): Detection and measurement of an immune response in a solution. The presence of antigens or antibodies is verified and visualized with an application of tagged antibodies. It is generally less sensitive than nucleic acid-based amplification techniques.
- Ligase Chain Reaction (LCR): A technique for the detection of any defined DNA sequence by amplification of ligation products complementary to the target sequence. Similar to PCR, this method allows the detection of minute levels of known nucleic acid sequences.
- Nucleic Acid Sequence-based Amplification (NASBA): Alternative to PCR, whereby RNA or DNA is selectively amplified through continual amplification at a constant temperature.
- Strand Displacement Amplification (SDA): In contrast to other techniques, which rely on thermal cycling, SDA is an isothermal process (entire reaction is performed at a uniform temperature) that employs a series of primers, DNA polymerase, and a restriction enzyme to exponentially amplify the target nucleic acid sequence.
- Transcription Mediated Amplification (TMA): An isothermal RNA transcription amplification technique employing RNA polymerase and reverse transcriptase to drive the reaction. TMA can amplify either DNA or RNA, producing an RNA amplicon, in contrast to most other nucleic acid amplification methods that only produce DNA.
- Point-of-care Testing (POCT): Pathology investigation by or on behalf of the treating medical practitioner on-site. It is a diagnostic testing conducted close to the site where clinical care is delivered.
- Automation: Laboratory automation can be defined broadly as any device, software, or process that improves the efficiency of the laboratory.
- Integration: The act of integrating various automated tasks into a continuous process.

Market Overview

Healthcare Challenges among Growing Asian Economies help Create Growth Opportunities
The boom in economic growth among Asian countries is leading to considerable inequalities in healthcare provisions. In addition to the challenges of a rapidly increasing aged population, healthcare systems across the region are being confronted with the looming danger of infectious diseases As a result, there is an increasing need for fast and specific diagnosis and confirmation of diseases in order to control potential epidemics. This is paving the way for increased growth of the nucleic acid testing (NAT) markets in Asia. The threat of emerging infectious diseases such as avian flu and increasing disease burdens of HIV and tuberculosis are critical contributing factors to the growth opportunities in the NAT markets.
Conventional diagnostic methods such as cell culture, antibody testing, and even symptomatic diagnosis consume considerable time as compared to NAT. A polymerase chain reaction (PCR) test only takes 30 minutes to deliver results. It also requires minimal staff training and expertise due to its simple operations. Furthermore, data is verified with the included set of standards and a positive and negative control may also be further added. Constant improvements in technology have made NAT comparable to dip-sticks on the time front, thus making it a favored method of diagnosis, explains the analyst of this research service. In terms of sensitivity and specificity, NAT has a clear advantage over conventional immunoassay or serotyping, as it is not dependent on the operators personal judgment, and these inherent advantages are proving to be strong drivers for their increasing adoption throughout the region.

Increased Incidence and Prevalence of Infectious Disease Encourage the Adoption of NAT Technology
Since the severe acute respiratory syndrome (SARS) epidemic and the food poisoning due to Norovirus in January 2004, a lot of attention has been focused on NAT methods in Singapore. For example, during the dengue epidemic in 2005, the healthcare industry had resorted to using NAT with promising outcomes. The SARS epidemic also provided an entry point for the increased penetration of NAT technology into the markets in China and Hong Kong, where research projects are primarily focused on the study of infectious diseases using NAT. In Malaysia, viral and bacterial diseases are the key revenue drivers for the NAT market and dengue fever, tuberculosis, HIV, and viral hepatitis were the diseases with highest incidences in 2005.
Considering the limitation in funding as well as the transition time needed to fully adopt NAT into existing practices, the overall NAT market in Asia Pacific is likely to grow at a medium pace. Although initial adoption of the technology in the medical community has been slow, NAT is slowly but definitely becoming a recognized and preferred diagnostic tool, says the analyst. Additionally, an increase in research employing molecular biology related protocols is also driving the demand for more NAT-related technologies in Asia.










Table of contents:
 1. Research and Market Overview

- 1. Research Overview

- - 1. Research Scope and Methodology

- - 2. Research Process

- - 3. Glossary of Terms

- 2. Market Overview

- - 1. Introduction

- - 2. Market Drivers-- a. Threat of Infectious Disease Outbreak-- b. Performance - Speed, Specificity and Sensitivity-- c. Increasing Government Funding For Life Science Research-- d. Increased Expenditure On Healthcare-- e. Change In Disease Testing Profile-- f. Effort of Deparment of Health in Promoting NAT

- - 3. Market Restraints-- a. High Cost of NAT Testing-- b. Lack of Trained / Skilled NAT Operators-- c. Low Level of Awareness / Understanding of NAT-- d. Government Medical Subsidy And Healthcare Insurance-- e. Limited Range of NAT Products

- 2. Market Engineering Measurements

- 1. Introduction

- - 1. Overview

- 2. Market Analysis

- - 1. Market Age

- - 2. Market Revenue

- - 3. Market Revenue Growth Rate

- - 4. Price Range

- - 5. Price Sensitivity

- 3. End-user Analysis

- - 1. Customer Sites

- - 2. Customer Satisfaction

- - 3. Customer Loyalty

- 4. Technological Trends

- - 1. Current Technology Trends

- - 2. Point of Care Testing (POCT)

- - 3. Degree of Technical Change/Future Potential

- 5. Distribution Structure and Trends

- - 1. Market Distribution Structure and Trends

- 3. Competitive Analysis and Revenue Forecasts

- 1. Competitive Structure

- - 1. Competitors

- 2. Revenue Forecast

- - 1. Revenue Forecast

- - 2. Market Growth Rate During the Forecast Period

- 4. Disease Profile

- 1. Disease Profile in Hong Kong

- - 1. The Disease Profile

- 5. Conclusion

- 1. Strategic Recommendations

- - 1. Recommendations

- 6. Appendix

- 1. Appendix

- - 1. Organizational Structure of the Public Healthcare Delivery System (Hong Kong) in 2005

- - 2. Fee Structure of the Public Healthcare Sector (Hong Kong) in 2005

- - 3. Amount of Competitive Research Grant Approved by UGC in U.S.dollars during 2000 - 2006

- - 4. Biotechnology-related Projects Funded Under the Areas of Excellence Scheme in UGC (Hong Kong) in 2005

- - 5. Key Indicators on Insurance Business Statistics (Hong Kong) during 2003-2004

- - 6. Number of Pathology Tests Conducted in All Hospital Authority Institutions in Hong Kong during 2003-2004

- - 7. Total Population in Hong Kong and Selected Major Countries from 2002 to 2012

- - 8. Nominal Gross Domestic Product in Hong Kong and Selected Major Countries from 2002 to 2012

- - 9. Total Healthcare Expenditure in Hong Kong and Selected Major Countries from 2002 to 2012 7. Frost & Sullivan Awards

- 1. Frost & Sullivan Awards - Asia Pacific

- - 1. Customer Service Leadership Award

- - 2. Technology Innovation Award

- - 3. Vertical Market Penetration Leadership Award

- - 4. Competitive Strategy Leadership Award

List Of Figures

Chapter 1

- NAT Market: Market Drivers Ranked in Order of Impact (Hong Kong), 2006-2010

- NAT Market: Amount of Funding for Biotechnology-related Research Projects from Various Agencies (Hong Kong), 2000-2006

- NAT Market: Healthcare Expenditure Profile (Hong Kong), 1997-2002

- NAT Market: Genetic Screening Programme (Hong Kong), 2002-2003

- NAT Market: HIV Test Performed by Government Public Health Laboratory (Hong Kong), 2001-2005

- NAT Market: Market Restraints Ranked in Order of Impact (Hong Kong), 2006-2010

Chapter 2

- NAT Market: Major Participants and their Distribution Channels (Hong Kong), 2005

Chapter 3

- NAT Market: Revenue Forecasts (Hong Kong), 2004-2010

Chapter 4

- NAT Market: Incidences of Communicable Diseases (Hong Kong), 2001-2005

Chapter 5

- NAT Market: Merger/Acquisition/Collaboration (Hong Kong), 2005

Chapter 6

- Decision Support Database: Fee Structure of the Public Healthcare Sector (Hong Kong), 2005

- Decision Support Database: Amount of Competitive Research Grant Approved by UGC in USD (Hong Kong), 2000-2006

- Decision Support Database: Biotechnology-related Projects Funded Under the Areas of Excellence Scheme, UGC (Hong Kong), 2005

- Decision Support Database: Key Indicators on Insurance Business Statistics (Hong Kong), 2003-2004

- Decision Support Database: Number of Pathology Tests Conducted in All Hospital Authority Institutions (Hong Kong), 2003-2004

- Decision Support Database: Total Population in Million (World), 2002-2012

- Decision Support Database: Nominal GDP in Billion USD (World), 2002-2012

- Decision Support Database: Total Healthcare Expenditure in Bn USD (World), 2002-2012

List of Charts

Chapter 2

- NAT Market: Market Engineering Measurements (Hong Kong), 2005

- NAT Market: Market Age (Hong Kong), 2005

Chapter 3

- NAT Market: Competitors (Hong Kong), 2005

- NAT Market: Revenue Forecasts (Hong Kong), 2004-2010

Chapter 5

- NAT Market: T.E.M.P. Approach (Hong Kong), 2005-2010

Chapter 6

- NAT Market: Organizational Structure of the Public Healthcare Delivery System (Hong Kong), 2005




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