The Bio-Detection markets present some of the fastest growing and vibrant markets in the Homeland Security industry. This research forecasts a 96% CAGR for 3rd-generation Bio-Detection technologies revenues between 2008 and 2012, which translates to an 80% market share for these technologies in 2012. The rapid growth for these 3rd generation technologies will coincide with a fast decline of 1st & 2nd -generation homeland security Bio-Detector markets which are forecasted to collapse at -20% CAGR. The growth of the 3rd generation technologies will result from the premium bio- agent selectivity, sensitivity and fast response coupled with a dramatic reduction in use of expensive reagents that these technologies are expected to provide.

HSRC's team of scientists and industry executives meticulously researched and analyzed each of the 4 modalities of bio-detection:

• Outdoor Automatic Standoff-Detectors (e.g., project BioWatch)
• Indoor Automatic Standoff-Detectors (e.g., Project BDS - U.S. Post Office)
• Emergency Responder Biological Mobile Labs
• Emergency Responder Biological Hand-Held Detectors

For each modality, the research provides a detailed analysis and forecast for 3 generations of technologies, providing for 12 the market segments that will make up this industry for the next 5 years.

For each of the 12 market segments, the research provides the following:

• Present & Next Generation Technologies - present technologies analysis and an in depth analysis of Bio-Detection candidates of next generation technologies
• Current and upcoming business opportunities -14 specific business opportunities outlined and analyzed
• 2007-2012 Market forecasts- Various and detailed forecasts including install base and annual sales in units and dollars, for the next 6 years
• 2007-2012 Service and upgrade business - 6 year forecasts of the service and equipment installation and upgrade business, which are the main source of gross margin for this industry

1. Scope

• 1.1. Definition of Biological Terrorism
• 1.2. Scope of This Report
• 1.2.1. Bio Weapon Types
• 1.3. Basic Assumptions
  • 1.3.1. General
  • 1.3.2. Why Conduct Constant Surveillance for Biological Warfare Threats?
  • 1.3.3. Possible Scenario Analysis
• 1.4. Methodology
  • 1.4.1. Research Methods
  • 1.4.2. Report Structure
• 1.5. Who is this report for?

2. Executive Summary

• 2.1. Main Conclusions
• 2.2. The Threat of BioTerrorism
• 2.3. How Real Is The Threat?
• 2.4. Defending Against BioTerrorism
  • 2.4.1. Project BioWatch
  • 2.4.2. Project BioSense
• 2.5. Bio-Detection - The Industry
• 2.6. Bio-Detection Market Forecast - 2007-2012
  • 2.6.1. Total Bio-Detection Systems and Service Market Forecast - 2007-2012
  • 2.6.2. Bio-Detection Systems & Service Market Forecast by Modality - 2007-2012
  • 2.6.3. Bio-Detection Market Forecast by Technology Generation - 2007-2012
• 2.7. Bio-Detection - Next Generation Business Opportunities
• 2.8. Technologies Outlook

3. Bio-Detection - Market Drivers - 2007-2012

4. Bio-Detection - Market Inhibitors - 2007-2012

5. The Threat of Bioterror

• 5.1. Use of Bioweapons - Historical Perspective
• 5.2. Biological Terror - Bacterial Agents
  • 5.2.1. Anthrax
  • 5.2.2. Cholera
  • 5.2.3. Plague
  • 5.2.4. Tularemia
• 5.3. Biological Terror - Viral Agents
  • 5.3.1. Smallpox
  • 5.3.2. Hemorrhagic Fever Viruses
  • 5.3.3. Venezuelan Equine Encephalitis
• 5.4. Biological Terror - Rickettsiae Agents
  • 5.4.1. Q Fever
  • 5.4.2. Typhus
• 5.5. Biological Terror - Toxins
  • 5.5.1. Botulinum Toxin
  • 5.5.2. Ricin
  • 5.5.3. Saxitoxin
  • 5.5.4. Staphylococcal Enterotoxin B (SEB)

6. Bio-Detection - Technology & System Requirements

• 6.1. Defining the Problem
  • 6.1.1. Sampling the environment
• 6.2. Stages of a Bio-Detection Process
  • 6.2.1. Biodetectors in a Multitude of Ambient Settings
  • 6.2.2. Process Triggering
  • 6.2.3. Collection of Particles
  • 6.2.4. BioParticle Detector
  • 6.2.5. Agent Identification
• 6.3. Bio-Detection/Performance Challenges
  • 6.3.1. Challenge 1 - The need to detect a very small particle Concentration
  • 6.3.2. Challenge 2 - Eliminating strong background
  • 6.3.3. Challenge 3 - High usage of expensive reagents
  • 6.3.4. Challenge 4 - Expensive maintenance of equipment
  • 6.3.5. Challenge 5 - Suitability of equipment to changing environments
  • 6.3.6. Challenge 6 - Dealing with emerging threats
• 6.4. Bio-Detection - Core Technologies Comparison
• 6.5. Collector/Concentrator Core Technologies
  • 6.5.1. Cyclone Collectors
  • 6.5.2. Variable Particle-Size Impactor
  • 6.5.3. Virtual Impactors
  • 6.5.4. Impingers
• 6.6. Reagentless Trigger Core Technologies
  • 6.6.1. Flow Cytometry
  • 6.6.2. Particle Sizing
  • 6.6.3. Gas Chromatography
  • 6.6.4. Trigger Technologies - Drivers
  • 6.6.5. Trigger Technologies - Inhibitors
• 6.7. DNA Based Diagnostic Core Technologies
  • 6.7.1. Overview of DNA-based Detection
  • 6.7.2. Polymerase Chain Reaction (PCR)
  • 6.7.3. DNA / RNA Microarrays
  • 6.7.4. DNA Technology Drivers
  • 6.7.5. DNA Technology Inhibitors
• 6.8. Antibody-Antigen Diagnostic Core Technologies
  • 6.8.1. Overview of Antibody-Antigen Reaction
  • 6.8.2. Hand-Held Immuno-Chromatographic Assays (HHA)
  • 6.8.3. Magnetic Microbead-base Assays
  • 6.8.4. Microfluidic Devices - "Lab on Chips"
  • 6.8.5. Fluorescence Imaging
  • 6.8.6. Electrochemical-Luminescence (ECL)
  • 6.8.7. Antibody/Antigen Technology - Drivers
  • 6.8.8. Antibody/Antigen Technology - Inhibitors
• 6.9. Signal Analysis Algorithms
  • 6.9.1. Clustering / Classifier Algorithms
  • 6.9.2. Image Analysis Algorithms
  • 6.9.3. Decision Algorithms
  • 6.9.4. Algorithm Drivers
  • 6.9.5. Algorithm Inhibitors
• 6.10. Biological Detection - Overview by Application
  • 6.10.1. Application 1 - Emergency Responder Hand-Held Detectors
  • 6.10.2. Application 2 - Emergency Responder Mobile Labs
  • 6.10.3. Application 3 - Indoor Standoff Detectors
  • 6.10.4. Application 4 - Outdoor Standoff Detectors

7. Bio-Detection - Systems HLS Market Outlook - 2007-2012

• 7.1. Scope, Assumptions and Overview
  • 7.1.1. Scope
• 7.2. Bio-Detection - Systems Revenue Sales Forecast - 2007-2012
  • 7.2.1. Bio-Detection - Systems Revenue Sales by Generation Forecast - 2007-2012
  • 7.2.2. Bio-Detection - Systems Revenue Sales by Modality Forecast - 2007-2012
• 7.3. Bio-Detection - Systems Quantity Sales Forecast - 2007-2012
  • 7.3.1. Bio-Detection - Systems Quantity Sales by Generation Forecast - 2007-2012
  • 7.3.2. Bio-Detection - Systems Quantity Sales by Modality Forecast - 2007-2012
• 7.4. Bio-Detection - Systems Installed Base Forecast - 2007-2012
  • 7.4.1. Bio-Detection - Systems Installed Base by Generation Forecast - 2007-2012
  • 7.4.2. Bio-Detection - Systems Installed Base by Modality Forecast - 2007-2012
• 7.5. Bio-Detection -Outdoor Standoff-Detection Systems - Market Forecast - 2007-2012
  • 7.5.1. Outdoor Standoff Detection Systems Revenue Sales Outlook - 2007-2012
  • 7.5.2. Outdoor Standoff Detection Systems Quantity Sales Outlook - 2007-2012
  • 7.5.3. Outdoor Standoff Detection Systems - Installed Base Outlook - 2007-2012
• 7.6. Bio-Detection - Indoor Systems Standoff-Detection Market Forecast - 2007-2012
  • 7.6.1. Indoor Standoff Systems Detection Revenue Sales Outlook - 2007-2012
  • 7.6.2. Indoor Standoff Detection Systems Unit Sales Outlook - 2007-2012
  • 7.6.3. Indoor Standoff Detection Systems - Installed Base - 2007-2012
• 7.7. Bio-Detection - Point-Detection (Detect-to-Treat) Systems - Installed Base Forecast - 2007-2012
  • 7.7.1. Point-Detection Summary Overview
• 7.8. Bio-Detection - First Responder Hand-Held Detection Systems - Market Forecast - 2007-2012
  • 7.8.1. First Responder Hand-Held Detection Systems - Sales Revenue Outlook - 2007-2012
  • 7.8.2. First Responder Hand-Held Detection Systems - Quantity Sales Outlook - 2007-2012
  • 7.8.3. First Responder Hand-Held Detection Systems - Installed Base - 2007-2012
• 7.9. Bio-Detection - First Responder Mobile Labs Detection Systems - Market Forecast - 2007-2012
  • 7.9.1. First Responder Mobile Labs - Revenue Sales Outlook - 2007-2012
  • 7.9.2. First Responder Mobile Labs - Quantity Sales Outlook - 2007-2012
  • 7.9.3. First Responder Mobile Labs - Installed Base - 2007-2012

8. Bio-Detection - Service Business Outlook - 2007-2012

• 8.1. Bio-Detection - Service Business Forecast by Modality - 2007-2012
• 8.2. Bio-Detection - Service Business Forecast by Technology Generation - 2007-2012

9. Bio-Detection - Business Opportunities - 2007-2012

• 9.1. Historical Perspective: A Market Waiting for Transition
  • 9.1.1. The Current and Future HLS Biodefense Strategy for Detection
  • 9.1.2. Factors Affecting Biological Detectors Deployment and Technologies 2007-2012
  • 9.1.3. Biological Detection Technology Timeline - 1992-2012
• 9.2. Business Opportunities for Next Generation Biological Detection Systems
  • 9.2.1. Business Opportunity 1 - Emerging Threats
  • 9.2.2. Business Opportunity 2 - Human Sentinel Surveillance System
  • 9.2.3. Business Opportunity 3 - Animal Sentinel Surveillance System
  • 9.2.4. Business Opportunity 4 - Biological IC3 - Biological Threat Assessment Intelligence Command, Control, and Communication Infrastructure
  • 9.2.5. Business Opportunity 5 - Reducing False Alarms - Lesser False Positives and False Negatives
  • 9.2.6. Business Opportunity 6 - Reducing Cost - Minimizing Use of Non-Reusable Reagents
• 9.3. Outdoor Standoff Biological Detectors
  • 9.3.1. Business Opportunity 7 - Bioagent Autonomous Networked Detectors (BAND)
  • 9.3.2. Business Opportunity 8 - Rapid Automated Biological Identification System (RABIS)
  • 9.3.3. Business Opportunity 9 - First Responder Portable Hand-Held Detector
  • 9.3.4. Business Opportunity 10 - First Responder Mobile Biological Detection Station
  • 9.3.5. Business Opportunity 11 - Regional Automatic Detector - Outdoor Standoff Detectors
  • 9.3.6. Business Opportunity 12 - Networked Automatic Detector - Indoor Standoff Detectors
  • 9.3.7. Business Opportunity 13 - External Spread of Bioagent Detection
  • 9.3.8. Business Opportunity 14 - Internal Spread of Bioagent
• 9.4. Other Bio-Detection Technologies - Business Opportunities
  • 9.4.1. Business Opportunity 15 - "Lab On Chip" - Miniature Detection Devices
  • 9.4.2. Business Opportunity 16 - Reagentless Specific Detection Assays
  • 9.4.3. Business Opportunity 17 - Laser Induced Breakdown Spectroscopy (LIBS)
  • 9.4.4. Business Opportunity 18 - Raman Spectroscopybased Reagentless Detection
• 9.5. Future Technologies and Systems

10. Bio-Detection R&D - Federal R&D Funding Opportunities - 2007-2012

• 10.1. Summary & Outlook
• 10.2. Bio-Detection - Federal R&D Funding Forecast - 2007-2012
  • 10.2.1. DHS - Bio-Detection R&D
  • 10.2.2. DOD - Bio-Detection R&D
  • 10.2.3. TSWG - Bio-Detection R&D
• 10.3. Bio-Detection - R&D Opportunities Forecast - 2007-2012
• 10.4. Bio-Detection - R&D Funding Opportunities Drivers - 2007-2012
• 10.5. Bio-Detection - R&D Funding Opportunities Inhibitors - 2007-2012
• 10.6. DHS - Biological Detection HLS Technologies R&D Programs
  • 10.6.1. Surveillance and Detection R&D
  • 10.6.2. Rapid Development for Sensors for Novel Threat Agents
  • 10.6.3. Cross Correlation of Environmental Biological Sensors and Human Illness
  • 10.6.4. Facility Airborne Biological Toxin Alarm System (FABTAS)
  • 10.6.5. Field-Deployable Detection Technology for the Identification of Biological Toxins
  • 10.6.6. Forensics
• 10.7. DARPA (DOD) - Biological Detection HLS Technologies R&D Programs
  • 10.7.1. Handheld Isothermal Silver Standard Sensor (HISSS)
  • 10.7.2. Triangulation Identification for Genetic Evaluation of Biological Risk (TIGER)
  • 10.7.3. Spectral Sensing of Bio-Aerosols (SSBA)
  • 10.7.4. Threat Agent Cloud Tactical Intercept Countermeasure (TACTIC)
  • 10.7.5. Immune Buildings
• 10.8. CBDP (DOD) - Biological Detection HLS Technologies R&D Programs
  • 10.8.1. Project CB1 - Biological Defense (Basic Research) - Detection
  • 10.8.2. Project CB2 - Biological Defense (Applied Research) - Detection
  • 10.8.3. Project CB3 - Biological Defense (ATD) - Detection
  • 10.8.4. Project CA5 Contamination Avoidance (SDD)
• 10.9. TSWG - Biological Detection HLS Technologies R&D Programs
  • 10.9.1. Real-Time Biological Aerosol Detection

11. Bio-Detection - Pricing Outlook - 2007-2012

12. Bio-Detection - Economic Considerations

• 12.1. Overview
• 12.2. Economical Analysis - Assumptions
  • 12.2.1. Bio-Detection - Economic Analysis
  • 12.2.2. Cost of Equipment Ownership
  • 12.2.3. Cost of Personnel/Year
  • 12.2.4. Cost of Test

13. Bio-Detection - Personnel Considerations

• 13.1. Background - Personnel
• 13.2. Personnel Training

14. Bio-Detection - Vendors

• 14.1. Vendors and Products
  • 14.1.1. Biological Detection Equipment - Hand Held
  • 14.1.2. Biological Detection Equipment - Mobile Laboratory
  • 14.1.3. Biological Detection Equipment - Fixed Site
  • 14.1.4. Biological Detection Equipment - Standoff Detectors
  • 14.1.5. Biological Screening Equipment - Hand-Held
  • 14.1.6. Biological Screening Equipment - Mobile Laboratory
  • 14.1.7. Biological Screening Equipment - Fixed Site
• 14.2. Biological Sampling Equipment
  • 14.2.1. Sorted by Biological Sampling Equipment Vendors and Technologies
  • 14.2.2. Biological Reagent Kits

15. Bio-Detection - Patent Review

• 15.1. Scope
• 15.2. Bio-Detection Patents

16. Bio-Detection - Legal Issues

• 16.1. International / European Legislation / Agreements
  • 16.1.1. The Biological and Toxin Weapons Convention (BTWC) 1972
• 16.2. U.S. Bio-Detection Homeland Security Legislation